Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 187
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 131
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 131
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 93
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 36
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
VCP P55072 valosin containing protein 1.00 0.469 0.923 193
FLNB O75369 filamin B 6.1E-10 0.458 0.923 173
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 154
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 147
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 147
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 132
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 125
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 119
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 82
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 67
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 62
MMP13 P45452 matrix metallopeptidase 13 Enzyme 7.9E-18 0.452 0.923 49
ABL1 P00519 ABL proto-oncogene 1, non-receptor tyrosine kinase Kinase 1.00 0.432 0.923 43
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 29
AIMP2 Q13155 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 8.0E-03 0.393 0.923 24
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 19