Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ABCC2 Q92887 ATP binding cassette subfamily C member 2 Transporter 5.2E-47 0.483 0.808 16
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 8
ABCG2 Q9UNQ0 ATP binding cassette subfamily G member 2 (Junior blood group) Transporter 2.1E-32 0.419 0.885 7
ABCC8 Q09428 ATP binding cassette subfamily C member 8 Transporter 8.0E-24 0.474 0.846 12
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
SSTR4 P31391 somatostatin receptor 4 G-protein coupled receptor 3.7E-13 0.469 0.846 1
OGG1 O15527 8-oxoguanine DNA glycosylase 3.9E-12 0.453 0.808 9
NT5E P21589 5'-nucleotidase ecto Enzyme 2.3E-11 0.436 0.885 2
MFN1 Q8IWA4 mitofusin 1 Enzyme 2.5E-10 0.644 0.577 10
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 26
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.2E-09 0.434 0.885 40
GRIK1 P39086 glutamate ionotropic receptor kainate type subunit 1 Ion channel 1.2E-09 0.641 0.462 1
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 9
RGS4 P49798 regulator of G protein signaling 4 Enzyme modulator 5.1E-08 0.621 0.577 8
GJB6 O95452 gap junction protein beta 6 Cell-cell junction 1.7E-07 0.528 0.808 7
APEX1 P27695 apurinic/apyrimidinic endodeoxyribonuclease 1 1.9E-07 0.458 0.846 7
AQP1 P29972 aquaporin 1 (Colton blood group) Ion channel 2.6E-07 0.467 0.885 9
CYP11A1 P05108 cytochrome P450 family 11 subfamily A member 1 5.5E-07 0.547 0.731 10
AIF1 P55008 allograft inflammatory factor 1 Calcium-binding protein 1.9E-06 0.521 0.808 17
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 26
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 31
CKMT1B P12532 creatine kinase, mitochondrial 1B Kinase 3.2E-05 0.729 0.346 1
ALAD P13716 aminolevulinate dehydratase Enzyme 5.6E-05 0.556 0.615 13
PLAT P00750 plasminogen activator, tissue type Enzyme 5.7E-05 0.445 0.885 15