Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 128
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 187
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 49
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 125
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 62
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 82
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 73
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 29
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 106
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 93
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 303
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 245
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 74
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 147
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 66
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 142
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 83
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 140
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 301