Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 684 974
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808 490 777
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808 526 757
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
FBXO11 Q86XK2 F-box protein 11 Enzyme 1.00 0.604 0.692 93 619
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 664 387
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 469 292
KMT2D O14686 lysine methyltransferase 2D 1.00 0.465 0.808 320 266
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808 291 194
CDH1 P12830 cadherin 1 0.15 0.401 0.808 508 187
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1394 183
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 854 163
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808 319 157
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
GLDC P23378 glycine decarboxylase Enzyme 6.6E-28 0.628 0.577 78 146
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 372 145
FH P07954 fumarate hydratase Enzyme 8.8E-02 0.489 0.846 231 143
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137