Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 960 48
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 693 64
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 653 35
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 551 52
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 521 38
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.444 0.846 496 96
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 460 26
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 438 123
JAG1 P78504 jagged canonical Notch ligand 1 1.00 0.429 0.808 420 63
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 384 30
PTPRC P08575 protein tyrosine phosphatase receptor type C Enzyme 1.00 0.435 0.808 366 18
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 345 48
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846 341 22
BRD4 O60885 bromodomain containing 4 Epigenetic regulator 1.00 0.446 0.885 335 6
KMT2D O14686 lysine methyltransferase 2D 1.00 0.465 0.808 320 266
PRKCB P05771 protein kinase C beta Kinase 1.00 0.453 0.885 317 18
BCOR Q6W2J9 BCL6 corepressor 1.00 0.471 0.808 314 21
FLT4 P35916 fms related receptor tyrosine kinase 4 Kinase 1.00 0.457 0.808 306 19
TEK Q02763 TEK receptor tyrosine kinase Kinase 1.00 0.462 0.692 300 17
HDAC6 Q9UBN7 histone deacetylase 6 Epigenetic regulator 1.00 0.465 0.846 288 1