Source: GENOMICS_ENGLAND

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
DNAJB2 P25686 DnaJ heat shock protein family (Hsp40) member B2 5.4E-05 0.743 0.192 2
CACNB4 O00305 calcium voltage-gated channel auxiliary subunit beta 4 Ion channel 3.1E-02 0.653 0.231 6
ZFYVE27 Q5T4F4 zinc finger FYVE-type containing 27 1.1E-09 0.805 0.308 2
COQ8A Q8NI60 coenzyme Q8A Kinase 9.3E-11 0.674 0.385 4
TTBK2 Q6IQ55 tau tubulin kinase 2 Kinase 1.00 0.682 0.423 2
NIPA1 Q7RTP0 NIPA magnesium transporter 1 Transporter 5.9E-03 0.682 0.462 2
KCNC3 Q14003 potassium voltage-gated channel subfamily C member 3 Ion channel 0.21 0.705 0.462 2
APTX Q7Z2E3 aprataxin Nucleic acid binding 4.0E-10 0.590 0.500 4
SPG21 Q9NZD8 SPG21 abhydrolase domain containing, maspardin 6.6E-04 0.695 0.500 2
PRKCG P05129 protein kinase C gamma Kinase 1.00 0.617 0.500 2
SPG11 Q96JI7 SPG11 vesicle trafficking associated, spatacsin 1.6E-39 0.576 0.538 4
TDP1 Q9NUW8 tyrosyl-DNA phosphodiesterase 1 Enzyme 1.3E-17 0.612 0.538 2
KCNA1 Q09470 potassium voltage-gated channel subfamily A member 1 Ion channel 7.6E-02 0.573 0.577 4
SPAST Q9UBP0 spastin Cellular structure 1.00 0.579 0.577 4
PHYH O14832 phytanoyl-CoA 2-hydroxylase 2.4E-06 0.659 0.577 3
SLC1A3 P43003 solute carrier family 1 member 3 Transporter 0.99 0.573 0.577 3
TTPA P49638 alpha tocopherol transfer protein Transporter 1.4E-03 0.612 0.577 3
SCN9A Q15858 sodium voltage-gated channel alpha subunit 9 Ion channel 4.8E-19 0.543 0.615 9
PEX7 O00628 peroxisomal biogenesis factor 7 8.2E-13 0.603 0.615 6
WASHC5 Q12768 WASH complex subunit 5 Transporter 8.3E-18 0.572 0.615 3
ZFYVE26 Q68DK2 zinc finger FYVE-type containing 26 4.7E-23 0.636 0.615 2
SPART Q8N0X7 spartin 3.0E-07 0.588 0.654 4
FXN Q16595 frataxin Enzyme 0.34 0.510 0.654 4
SACS Q9NZJ4 sacsin molecular chaperone 1.1E-23 0.606 0.654 3