Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 26
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 26
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 26
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
MIF P14174 macrophage migration inhibitory factor 1.2E-02 0.412 0.885 26
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885 26
CYP2E1 P05181 cytochrome P450 family 2 subfamily E member 1 8.1E-09 0.459 0.885 24
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 24
CASP12 Q6UXS9 caspase 12 (gene/pseudogene) 1.3E-04 0.638 0.808 23
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 23
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 23
AGTR2 P50052 angiotensin II receptor type 2 G-protein coupled receptor 8.2E-03 0.496 0.808 22
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 21
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885 21
NPPB P16860 natriuretic peptide B 9.9E-06 0.513 0.808 20
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 20
CD36 P16671 CD36 molecule Receptor 1.1E-60 0.446 0.846 19
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 18
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692 18
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 18
SERPINF1 P36955 serpin family F member 1 Enzyme modulator 7.8E-08 0.460 0.846 18
UCP2 P55851 uncoupling protein 2 Transporter 1.5E-10 0.493 0.808 18