Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 186
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 185
BCOR Q6W2J9 BCL6 corepressor 1.00 0.471 0.808 180
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
ND4 P03905 NADH dehydrogenase, subunit 4 (complex I) Enzyme 0.546 0.769 175
TRNW tRNA 0.563 0.731 175
RYR1 P21817 ryanodine receptor 1 Ion channel 1.6E-29 0.489 0.808 173
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 173
PEX1 O43933 peroxisomal biogenesis factor 1 1.1E-14 0.538 0.769 171
TRNS1 tRNA 0.555 0.808 170
SDHA P31040 succinate dehydrogenase complex flavoprotein subunit A Enzyme 2.6E-10 0.517 0.731 168
SMARCB1 Q12824 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Nucleic acid binding 1.00 0.434 0.846 163
PIEZO2 Q9H5I5 piezo type mechanosensitive ion channel component 2 Ion channel 8.1E-07 0.529 0.769 159
SKI P12755 SKI proto-oncogene 1.00 0.503 0.808 159
DHCR7 Q9UBM7 7-dehydrocholesterol reductase Enzyme 3.9E-13 0.500 0.846 158
GP1BB P13224 glycoprotein Ib platelet subunit beta 0.51 0.524 0.769 158
SMC1A Q14683 structural maintenance of chromosomes 1A 1.00 0.509 0.808 157
TPM2 P07951 tropomyosin 2 Cellular structure 2.4E-04 0.530 0.654 157
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 155
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 154
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 154
MKS1 Q9NXB0 MKS transition zone complex subunit 1 Extracellular structure 3.4E-16 0.505 0.769 153
NAA10 P41227 N-alpha-acetyltransferase 10, NatA catalytic subunit Enzyme 0.76 0.535 0.692 153
PEX6 Q13608 peroxisomal biogenesis factor 6 6.3E-06 0.547 0.731 153