Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
DCTN1 Q14203 dynactin subunit 1 Chaperone 8.4E-02 0.597 0.500 65
EIF2S3 P41091 eukaryotic translation initiation factor 2 subunit gamma Enzyme 0.96 0.604 0.731 63
DNAJC6 O75061 DnaJ heat shock protein family (Hsp40) member C6 1.00 0.641 0.385 61
HNF1A P20823 HNF1 homeobox A Nucleic acid binding 0.96 0.478 0.846 60
MATR3 P43243 matrin 3 1.00 0.631 0.538 60
TARDBP Q13148 TAR DNA binding protein 0.99 0.493 0.808 60
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808 59
HTT P42858 huntingtin 1.00 0.548 0.654 58
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 58
PAK3 O75914 p21 (RAC1) activated kinase 3 Kinase 0.99 0.569 0.731 58
UCHL1 P09936 ubiquitin C-terminal hydrolase L1 Enzyme 0.99 0.482 0.885 57
HTRA2 O43464 HtrA serine peptidase 2 3.6E-03 0.542 0.692 56
PODXL O00592 podocalyxin like 1.0E-03 0.551 0.731 55
CFAP410 O43822 cilia and flagella associated protein 410 3.3E-07 0.633 0.615 54
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846 53
NEFH P12036 neurofilament heavy 2.7E-12 0.588 0.769 53
TSHR P16473 thyroid stimulating hormone receptor G-protein coupled receptor 3.0E-15 0.486 0.808 53
PTS Q03393 6-pyruvoyltetrahydropterin synthase 6.5E-06 0.636 0.654 51
GABBR2 O75899 gamma-aminobutyric acid type B receptor subunit 2 G-protein coupled receptor 1.00 0.650 0.538 50
NAGS Q8N159 N-acetylglutamate synthase 4.0E-08 0.716 0.423 49
PSEN2 P49810 presenilin 2 Enzyme 5.4E-04 0.550 0.654 47
ACAT1 P24752 acetyl-CoA acetyltransferase 1 Enzyme 9.9E-08 0.538 0.692 46
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846 46
NDST1 P52848 N-deacetylase and N-sulfotransferase 1 1.00 0.608 0.692 45