Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
FLNA P21333 filamin A 1.00 0.419 0.846 298
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.444 0.846 261
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 238
RRM2B Q7LG56 ribonucleotide reductase regulatory TP53 inducible subunit M2B Enzyme 2.4E-03 0.527 0.769 153
SLC26A2 P50443 solute carrier family 26 member 2 Transporter 7.5E-07 0.553 0.692 149
WDR35 Q9P2L0 WD repeat domain 35 1.0E-22 0.525 0.692 148
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 147
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 141
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808 132
STAT4 Q14765 signal transducer and activator of transcription 4 Nucleic acid binding 0.77 0.471 0.769 125
FLI1 Q01543 Fli-1 proto-oncogene, ETS transcription factor Transcription factor 0.99 0.468 0.692 124
LRP5 O75197 LDL receptor related protein 5 0.51 0.485 0.846 124
HESX1 Q9UBX0 HESX homeobox 1 8.0E-04 0.561 0.654 116
IL12A P29459 interleukin 12A 4.7E-02 0.491 0.808 105
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 103
POLG2 Q9UHN1 DNA polymerase gamma 2, accessory subunit Enzyme 1.5E-10 0.558 0.769 96
TCTN2 Q96GX1 tectonic family member 2 1.8E-14 0.578 0.654 96
PSAP P07602 prosaposin 0.99 0.532 0.846 92
TRIP11 Q15643 thyroid hormone receptor interactor 11 1.7E-12 0.595 0.654 92
HLA-DQB1 P01920 major histocompatibility complex, class II, DQ beta 1 Immune response 8.9E-03 0.407 0.885 90
NKX2-1 P43699 NK2 homeobox 1 Transcription factor 0.36 0.457 0.808 80
WDR60 Q8WVS4 WD repeat domain 60 Cellular structure 4.3E-12 0.592 0.654 80
DYNC2H1 Q8NCM8 dynein cytoplasmic 2 heavy chain 1 Enzyme 1.1E-44 0.555 0.731 79
C1R P00736 complement C1r Enzyme 0.78 0.638 0.654 77