Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2475 28
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 979 70
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 972 97
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 932 19
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 852 49
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 673 18
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 668 14
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 449 44
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 391 24
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 389 26
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 331 36
KRT7 P08729 keratin 7 3.1E-12 0.463 0.808 269 1
TET2 Q6N021 tet methylcytosine dioxygenase 2 4.3E-54 0.458 0.808 246 9
TAL1 P17542 TAL bHLH transcription factor 1, erythroid differentiation factor Transcription factor 0.57 0.505 0.731 196 1
BAG3 O95817 BAG cochaperone 3 0.62 0.498 0.846 187 5
PAFAH1B1 P43034 platelet activating factor acetylhydrolase 1b regulatory subunit 1 1.00 0.504 0.769 171 5
ASXL1 Q8IXJ9 ASXL transcriptional regulator 1 1.3E-14 0.482 0.808 165 2
ARSD P51689 arylsulfatase D Enzyme 1.6E-03 0.535 0.808 163 1
SERPING1 P05155 serpin family G member 1 Enzyme modulator 0.96 0.507 0.769 161 8
SCLY Q96I15 selenocysteine lyase Enzyme 2.3E-09 0.530 0.731 159 0
SF3B1 O75533 splicing factor 3b subunit 1 Nucleic acid binding 1.00 0.511 0.731 154 1
HTR1A P08908 5-hydroxytryptamine receptor 1A G-protein coupled receptor 0.20 0.522 0.846 148 8