Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2475 28
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1533 21
IFNG P01579 interferon gamma 0.47 0.288 0.962 1361 10
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1043 27
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 1034 19
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1030 52
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 994 8
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 972 97
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 957 6
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 953 13
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 762 4
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 757 66
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 706 18
MIR21 microRNA 21 0.363 0.846 705 2
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 704 15
MTCO2P12 MT-CO2 pseudogene 12 0.368 0.962 703 0
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 668 14
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 611 20
MAPK14 Q16539 mitogen-activated protein kinase 14 Kinase 0.37 0.379 0.923 594 5
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 584 17
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 584 17