Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 303
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
TBX1 O43435 T-box transcription factor 1 Transcription factor 0.84 0.433 0.808 199
MED12 Q93074 mediator complex subunit 12 Transcription factor 1.00 0.476 0.769 198
GLI3 P10071 GLI family zinc finger 3 1.00 0.436 0.846 193
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 186
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 173
RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) 0.556 0.808 167
DHCR7 Q9UBM7 7-dehydrocholesterol reductase Enzyme 3.9E-13 0.500 0.846 158
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 154
MKS1 Q9NXB0 MKS transition zone complex subunit 1 Extracellular structure 3.4E-16 0.505 0.769 153
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808 132
FLI1 Q01543 Fli-1 proto-oncogene, ETS transcription factor Transcription factor 0.99 0.468 0.692 124
GATA4 P43694 GATA binding protein 4 0.49 0.458 0.846 120
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 117
PTH1R Q03431 parathyroid hormone 1 receptor G-protein coupled receptor 0.57 0.544 0.731 115
PUF60 Q9UHX1 poly(U) binding splicing factor 60 1.00 0.536 0.769 111
BUB1B O60566 BUB1 mitotic checkpoint serine/threonine kinase B Kinase 7.0E-10 0.502 0.808 108
SPECC1L Q69YQ0 sperm antigen with calponin homology and coiled-coil domains 1 like 0.86 0.593 0.654 107
KDM6A O15550 lysine demethylase 6A Epigenetic regulator 1.00 0.498 0.769 106
SRY Q05066 sex determining region Y Transcription factor 0.456 0.808 105
KMT2D O14686 lysine methyltransferase 2D 1.00 0.465 0.808 98