Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
ALB P02768 albumin Transporter 0.64 0.317 0.962 1198 21
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 1059 13
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 823 34
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 783 28
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 724 10
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885 647 7
MAPK14 Q16539 mitogen-activated protein kinase 14 Kinase 0.37 0.379 0.923 626 7
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 603 4
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 575 144
FOS P01100 Fos proto-oncogene, AP-1 transcription factor subunit Transcription factor 0.26 0.411 0.885 528 3