Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 63
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 53
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 49
MUC1 P15941 mucin 1, cell surface associated 1.9E-02 0.384 0.885 40
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 37
FOXP3 Q9BZS1 forkhead box P3 0.99 0.368 0.846 36
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 36
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846 32
CFLAR O15519 CASP8 and FADD like apoptosis regulator Enzyme 1.00 0.485 0.846 24
BMP4 P12644 bone morphogenetic protein 4 Signaling 0.96 0.422 0.808 21
ITGAV P06756 integrin subunit alpha V 2.3E-04 0.526 0.769 21
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 20
GLI1 P08151 GLI family zinc finger 1 7.7E-14 0.431 0.846 20
MCL1 Q07820 MCL1 apoptosis regulator, BCL2 family member Signaling 0.96 0.430 0.808 18