Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 16
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 8
BLM P54132 BLM RecQ like helicase 1.5E-15 0.535 0.808 4
DDB2 Q92466 damage specific DNA binding protein 2 Nucleic acid binding 7.4E-06 0.576 0.654 4
ERCC3 P19447 ERCC excision repair 3, TFIIH core complex helicase subunit Enzyme 3.4E-11 0.504 0.846 4
ERCC5 P28715 ERCC excision repair 5, endonuclease 2.7E-13 0.499 0.731 4
XPA P23025 XPA, DNA damage recognition and repair factor Nucleic acid binding 7.9E-05 0.520 0.846 4
XPC Q01831 XPC complex subunit, DNA damage recognition and repair factor Nucleic acid binding 3.7E-11 0.504 0.808 4
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 3
DDR2 Q16832 discoidin domain receptor tyrosine kinase 2 Kinase 0.55 0.541 0.769 2