Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 78 47
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 72 928
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 57 2505
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846 48 17
DAPK1 P53355 death associated protein kinase 1 Kinase 1.00 0.472 0.808 43 3
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 40 44
JAG1 P78504 jagged canonical Notch ligand 1 1.00 0.429 0.808 35 60
AQP1 P29972 aquaporin 1 (Colton blood group) Ion channel 2.6E-07 0.467 0.885 35 3
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 31 120
KRT5 P13647 keratin 5 0.64 0.512 0.731 31 54
KMT2C Q8NEZ4 lysine methyltransferase 2C 1.00 0.558 0.692 29 7
ITGB4 P16144 integrin subunit beta 4 Receptor 9.5E-19 0.525 0.731 28 25
SETD2 Q9BYW2 SET domain containing 2, histone lysine methyltransferase Epigenetic regulator 1.00 0.424 0.846 28 20
ATRX P46100 ATRX chromatin remodeler 1.00 0.452 0.808 26 36
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 25 198
BCL11A Q9H165 BAF chromatin remodeling complex subunit BCL11A Transcription factor 0.97 0.541 0.769 25 50
FOXP2 O15409 forkhead box P2 1.00 0.545 0.808 25 22
MYCN P04198 MYCN proto-oncogene, bHLH transcription factor Transcription factor 0.89 0.454 0.808 24 14