Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 40
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 37
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 29
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 26
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 26
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 26
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 26
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 25
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 24
A2M P01023 alpha-2-macroglobulin Enzyme modulator 4.5E-11 0.529 0.769 20
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 20