Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 1157 8
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 750 18
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 724 10
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 721 25
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 689 68
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 679 23
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 668 32
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 666 9
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 662 37
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
EPO P01588 erythropoietin 1.1E-02 0.381 0.885 646 11