Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168 2
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 103 3
TRH P20396 thyrotropin releasing hormone 8.9E-04 0.519 0.846 100 1
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 91 10
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 90 28
IDH2 P48735 isocitrate dehydrogenase (NADP(+)) 2 0.88 0.434 0.808 83 5
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 77 931
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 73 6
TSC2 P49815 TSC complex subunit 2 Enzyme modulator 1.00 0.439 0.808 72 287
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 72 75
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 67 16
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 66 38
EPHX1 P07099 epoxide hydrolase 1 3.2E-09 0.500 0.846 63 0
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 60 28
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 57 2505
CST3 P01034 cystatin C 3.9E-03 0.436 0.808 55 6
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808 54 44
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 53 22
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 51 86