Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
LEP P41159 leptin 0.46 0.349 0.846 78
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 77
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 67
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 67
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 63
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 61
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 55
MBL2 P11226 mannose binding lectin 2 Receptor 2.7E-03 0.390 0.846 53
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 53