Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 59
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 51
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731 50
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 50
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 46
MUC1 P15941 mucin 1, cell surface associated 1.9E-02 0.384 0.885 40
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 39
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 39
MKI67 P46013 marker of proliferation Ki-67 1.3E-28 0.431 0.808 38
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808 37
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 36
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885 34
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 32
CDKN2B P42772 cyclin dependent kinase inhibitor 2B 7.3E-03 0.417 0.769 31
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 31