Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 67
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 66
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731 50
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 32
TNFSF13B Q9Y275 TNF superfamily member 13b 0.98 0.460 0.731 28
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885 27
TLR3 O15455 toll like receptor 3 Receptor 1.6E-07 0.427 0.885 24
CFTR P13569 CF transmembrane conductance regulator Ion channel 2.2E-58 0.424 0.885 21
S100A9 P06702 S100 calcium binding protein A9 Calcium-binding protein 0.48 0.433 0.885 21
LCN2 P80188 lipocalin 2 Enzyme 1.1E-09 0.405 0.885 20
S100A8 P05109 S100 calcium binding protein A8 Calcium-binding protein 0.14 0.430 0.962 18
MUC4 Q99102 mucin 4, cell surface associated 2.8E-54 0.506 0.769 15
CCL11 P51671 C-C motif chemokine ligand 11 Signaling 1.0E-02 0.473 0.885 14
CCL17 Q92583 C-C motif chemokine ligand 17 Signaling 1.4E-04 0.518 0.808 14
SCGB1A1 P11684 secretoglobin family 1A member 1 Signaling 8.0E-04 0.546 0.808 13
S100A7 P31151 S100 calcium binding protein A7 Calcium-binding protein 0.45 0.546 0.769 12
LGALS1 P09382 galectin 1 Signaling 4.5E-03 0.435 0.846 11
PEBP1 P30086 phosphatidylethanolamine binding protein 1 Enzyme modulator 9.2E-02 0.500 0.808 10