| Gene | Uniprot | Gene Full Name | Protein Class | pLI | DSI g | DPI g | Num. diseases | Num. SNPs |
|---|---|---|---|---|---|---|---|---|
| PIK3CA | P42336 | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Kinase | 1.00 | 0.292 | 0.923 | 85 | 55 |
| TP53 | P04637 | tumor protein p53 | Transcription factor | 0.53 | 0.236 | 0.962 | 84 | 390 |
| FGFR2 | P21802 | fibroblast growth factor receptor 2 | Kinase | 1.00 | 0.380 | 0.808 | 82 | 76 |
| HRAS | P01112 | HRas proto-oncogene, GTPase | Enzyme modulator | 8.0E-02 | 0.378 | 0.885 | 71 | 21 |
| PALB2 | Q86YC2 | partner and localizer of BRCA2 | 3.0E-19 | 0.485 | 0.769 | 48 | 393 | |
| NRAS | P01111 | NRAS proto-oncogene, GTPase | Enzyme modulator | 0.49 | 0.390 | 0.808 | 37 | 14 |