Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2245 232
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1533 21
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1308 143
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1294 19
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1214 67
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1173 9
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1160 28
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1156 29
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1043 27
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1030 52
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1011 29
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 983 56
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 953 13
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 942 62
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 888 48
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 805 39
H3P10 H3 histone pseudogene 10 0.350 0.846 769 0
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 762 4
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 757 66
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 748 8
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 747 8
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 739 21