Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 334
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 280
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 238
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 234
INS P01308 insulin 0.30 0.445 0.923 153
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 148
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 146
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 135
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 133
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 111
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 109
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923 106
LEP P41159 leptin 0.46 0.349 0.846 104
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885 99
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923 97
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 97
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 97
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 89
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 85
LEPR P48357 leptin receptor Signaling 0.99 0.433 0.808 79
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 76
GHRL Q9UBU3 ghrelin and obestatin prepropeptide 1.4E-11 0.517 0.769 67
PPARA Q07869 peroxisome proliferator activated receptor alpha Nuclear receptor 3.0E-02 0.432 0.885 66