Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
IFNG P01579 interferon gamma 0.47 0.288 0.962 1519 11
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1368 68
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1254 10
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 1157 8
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 995 85
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 859 12
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 854 163
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 774 33
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 770 23
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 754 47
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 722 24
MTCO2P12 MT-CO2 pseudogene 12 0.368 0.962 703 0