Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 58
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 45
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 41
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
XDH P47989 xanthine dehydrogenase Enzyme 2.6E-22 0.529 0.846 38
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 33
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846 31
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846 31