Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 84
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 77
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 77
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 71
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 67
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 67
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 63
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 55
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 53
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 52
VCAM1 P19320 vascular cell adhesion molecule 1 0.80 0.422 0.808 50
F5 P12259 coagulation factor V Enzyme 5.9E-15 0.441 0.846 47