Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 1157 8
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 1028 7
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 1002 19
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
LEP P41159 leptin 0.46 0.349 0.846 931 15
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 770 23
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 765 43
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 754 47
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 750 18
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 722 24
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 706 308
EPO P01588 erythropoietin 1.1E-02 0.381 0.885 646 11
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 644 54
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885 623 23
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 622 47
PLG P00747 plasminogen Enzyme 1.0E-02 0.389 0.923 586 34