Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846 559 31
ELN P15502 elastin 2.1E-14 0.415 0.885 545 61
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885 470 52
CCR7 P32248 C-C motif chemokine receptor 7 G-protein coupled receptor 5.8E-02 0.443 0.769 320 3
BCOR Q6W2J9 BCL6 corepressor 1.00 0.471 0.808 314 21
LIMK1 P53667 LIM domain kinase 1 Kinase 1.00 0.488 0.731 271 3
SOS1 Q07889 SOS Ras/Rac guanine nucleotide exchange factor 1 Enzyme modulator 1.00 0.485 0.808 261 41
SETBP1 Q9Y6X0 SET binding protein 1 1.00 0.503 0.808 257 28
SMC1A Q14683 structural maintenance of chromosomes 1A 1.00 0.509 0.808 251 53
GTF2I P78347 general transcription factor IIi 1.00 0.500 0.808 249 14
SALL4 Q9UJQ4 spalt like transcription factor 4 Transcription factor 1.00 0.489 0.769 245 17
HDAC8 Q9BY41 histone deacetylase 8 Epigenetic regulator 0.98 0.511 0.885 236 28
NIPBL Q6KC79 NIPBL cohesin loading factor Nucleic acid binding 1.00 0.521 0.808 225 270
PIEZO2 Q9H5I5 piezo type mechanosensitive ion channel component 2 Ion channel 8.1E-07 0.529 0.769 224 30
NSD2 O96028 nuclear receptor binding SET domain protein 2 Epigenetic regulator 1.00 0.507 0.769 224 4
GTF2IRD1 Q9UHL9 GTF2I repeat domain containing 1 0.90 0.522 0.769 222 8
POR P16435 cytochrome p450 oxidoreductase 3.4E-10 0.502 0.769 218 21