Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 135
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 110
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 90
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 85
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923 67
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 64
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 48
NPPB P16860 natriuretic peptide B 9.9E-06 0.513 0.808 48
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 41
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885 40
CDK6 Q00534 cyclin dependent kinase 6 Kinase 0.98 0.471 0.731 35
DES P17661 desmin 8.8E-03 0.460 0.846 33
MYH7 P12883 myosin heavy chain 7 4.2E-16 0.516 0.692 33
VWF P04275 von Willebrand factor Enzyme modulator 3.2E-25 0.408 0.885 33
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 32
SCN10A Q9Y5Y9 sodium voltage-gated channel alpha subunit 10 Ion channel 9.9E-38 0.566 0.692 28
CYP2C19 P33261 cytochrome P450 family 2 subfamily C member 19 6.5E-20 0.467 0.846 24
GATA4 P43694 GATA binding protein 4 0.49 0.458 0.846 24
MYH6 P13533 myosin heavy chain 6 1.6E-32 0.581 0.615 22
CGA P01215 glycoprotein hormones, alpha polypeptide 0.35 0.508 0.808 19
NKX2-5 P52952 NK2 homeobox 5 Transcription factor 0.95 0.533 0.692 19
TTN Q8WZ42 titin Kinase 2.6E-96 0.470 0.885 19
MIR30B microRNA 30b 0.555 0.808 18
SCN5A Q14524 sodium voltage-gated channel alpha subunit 5 Ion channel 0.91 0.513 0.654 18