Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 98 8
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 91 10
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 84 4
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 83 37
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 81 2
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 72 75
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 70 0
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 49 33