Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1737 58
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1533 21
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1334 32
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1050 26
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 972 97
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 826 38
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 757 66
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 584 17
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 555 4
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 546 5
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885 507 17
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 501 29
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 477 9
CYP19A1 P11511 cytochrome P450 family 19 subfamily A member 1 Enzyme 1.7E-05 0.410 0.885 448 54
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 444 2
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 422 24
PROM1 O43490 prominin 1 Transporter 1.9E-22 0.410 0.846 412 8
TTR P02766 transthyretin Transporter 0.52 0.423 0.885 404 48
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 400 14
TIMP2 P16035 TIMP metallopeptidase inhibitor 2 Enzyme modulator 0.79 0.425 0.846 364 13
FOS P01100 Fos proto-oncogene, AP-1 transcription factor subunit Transcription factor 0.26 0.411 0.885 361 3
EGR1 P18146 early growth response 1 Nucleic acid binding 0.35 0.433 0.923 335 3
VIP P01282 vasoactive intestinal peptide Signaling 4.2E-04 0.437 0.846 332 2
IGFBP3 P17936 insulin like growth factor binding protein 3 Enzyme modulator 0.91 0.439 0.808 316 10