Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923 1034 6
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 701 52
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 693 64
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 653 35
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 556 92
CDH1 P12830 cadherin 1 0.15 0.401 0.808 508 187
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 487 337
SQSTM1 Q13501 sequestosome 1 8.6E-04 0.428 0.885 470 43
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 460 26
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 452 109
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885 443 160
HFE Q30201 homeostatic iron regulator 2.6E-08 0.436 0.846 415 59
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 415 20
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808 412 75
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846 410 66
ABCB6 Q9NP58 ATP binding cassette subfamily B member 6 (Langereis blood group) Transporter 8.6E-19 0.431 0.885 400 19
ABL1 P00519 ABL proto-oncogene 1, non-receptor tyrosine kinase Kinase 1.00 0.432 0.923 395 37
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 377 15
SHBG P04278 sex hormone binding globulin 1.3E-06 0.438 0.808 368 20
TFRC P02786 transferrin receptor Enzyme 7.0E-05 0.437 0.885 359 40