Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 84
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 67
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 52
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 52
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 41
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
PLAUR Q03405 plasminogen activator, urokinase receptor 5.3E-03 0.536 0.731 35
NAT2 P11245 N-acetyltransferase 2 Enzyme 3.3E-06 0.451 0.885 33
APOA1 P02647 apolipoprotein A1 5.5E-04 0.429 0.885 31
THBS1 P07996 thrombospondin 1 1.00 0.407 0.885 31
S100B P04271 S100 calcium binding protein B Calcium-binding protein 4.4E-02 0.383 0.923 30
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 27
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 25
F2RL1 P55085 F2R like trypsin receptor 1 G-protein coupled receptor 1.5E-04 0.480 0.769 23