Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846 109 0
CRH P06850 corticotropin releasing hormone Signaling 0.72 0.439 0.808 107 2
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577 102 7
ADORA2A P29274 adenosine A2a receptor G-protein coupled receptor 0.60 0.526 0.769 101 0
PRL P01236 prolactin Signaling 2.9E-07 0.406 0.885 97 0
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885 93 2
HTR1A P08908 5-hydroxytryptamine receptor 1A G-protein coupled receptor 0.20 0.522 0.846 93 1
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 89 1
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 82 6
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 81 2
TAC1 P20366 tachykinin precursor 1 0.75 0.424 0.923 77 0
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 75 6