Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
LEP P41159 leptin 0.46 0.349 0.846 931 15
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 819 26
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 668 32
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 666 9
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 604 19
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 556 92
MIR146A microRNA 146a 0.398 0.885 505 3
F2 P00734 coagulation factor II, thrombin Enzyme 1.1E-03 0.415 0.885 490 42
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846 485 114
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 469 292
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 452 109