Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2475 28
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2245 232
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1737 58
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1533 21
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1308 143
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1294 19
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1277 41
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1214 67
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1173 9
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1156 29
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1105 16
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1087 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1077 12
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1011 29
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 999 26
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 994 8
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 983 56
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 957 6
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 953 13
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 951 4
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 932 19