Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2475 28
IL6 P05231 interleukin 6 0.32 0.248 0.962 2132 21
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1604 22
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1410 15
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1334 32
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 1173 9
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1160 28
ALB P02768 albumin Transporter 0.64 0.317 0.962 1089 13
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 979 70
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 972 97
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 957 6
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 926 22
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 886 50
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 839 55
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 839 21
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 826 38
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 816 57
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 717 26
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 706 18
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 673 18
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 668 14
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 641 11
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 632 35
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 600 18