Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 765 43
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 724 33
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 721 25
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 679 23
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 622 47
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885 616 11
FBN1 P35555 fibrillin 1 Calcium-binding protein 1.00 0.417 0.846 552 1105
CRK P46108 CRK proto-oncogene, adaptor protein 0.96 0.394 0.923 544 7
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 519 41
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 496 36
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 482 61
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 469 292
SYT1 P21579 synaptotagmin 1 Transporter 0.60 0.412 0.846 460 15
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 457 17