Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1394 183
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1368 68
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 1011 8
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 995 85
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 859 12
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 824 13
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 823 34
H3P10 H3 histone pseudogene 10 0.350 0.846 769 0
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600