Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 146 14
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 115 90
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 113 9
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
ADORA2A P29274 adenosine A2a receptor G-protein coupled receptor 0.60 0.526 0.769 101 0
EPO P01588 erythropoietin 1.1E-02 0.381 0.885 90 9
AVP P01185 arginine vasopressin Signaling 7.4E-02 0.437 0.846 78 18
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846 76 24
HGF P14210 hepatocyte growth factor Enzyme 1.00 0.374 0.885 73 6
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 70 0
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 69 3
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885 69 0
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 68 157
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 67 16