Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 1456 27
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1119 24
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1101 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 1011 8
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 996 23
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 859 12
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 821 17
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 783 28
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 653 35
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 644 54
IL13 P35225 interleukin 13 1.4E-02 0.386 0.846 587 9
KRT20 P35900 keratin 20 9.1E-11 0.388 0.846 559 1
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 551 52
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 521 38
HTC2 hypertrichosis 2 (generalized, congenital) 0.392 0.808 511 0
PDCD1 Q15116 programmed cell death 1 0.42 0.402 0.846 497 9
MS4A1 P11836 membrane spanning 4-domains A1 Receptor 5.1E-05 0.411 0.846 451 5
RPE65 Q16518 retinoid isomerohydrolase RPE65 Enzyme 6.5E-14 0.417 0.808 431 63
GATA3 P23771 GATA binding protein 3 0.90 0.415 0.846 429 30