Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 1558 50
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 1394 183
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ALB P02768 albumin Transporter 0.64 0.317 0.962 1198 21
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 873 39
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 824 13
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 823 34
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 783 28
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 749 15
CD44 P16070 CD44 molecule (Indian blood group) 2.4E-07 0.363 0.962 711 47
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 689 68
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 679 23
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 675 21
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 666 9
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25