Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 960 48
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 664 387
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 662 37
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 653 35
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
PRKAR1A P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 1.00 0.401 0.846 597 65
FLNA P21333 filamin A 1.00 0.419 0.846 571 85
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846 559 31
FBN1 P35555 fibrillin 1 Calcium-binding protein 1.00 0.417 0.846 552 1105
ELN P15502 elastin 2.1E-14 0.415 0.885 545 61
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 536 61
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.444 0.846 496 96