Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 40
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.2E-09 0.434 0.885 40
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 37
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 33
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846 31
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846 31
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 30
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 29
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 26
CYP2E1 P05181 cytochrome P450 family 2 subfamily E member 1 8.1E-09 0.459 0.885 24
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 24
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 21
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 21
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 20
ABCC3 O15438 ATP binding cassette subfamily C member 3 Transporter 1.2E-26 0.517 0.769 20
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 20
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 20