Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0013377
Disease: Dysgerminoma
Dysgerminoma 		0.010 Biomarker LHGDN This is the first report of Cowden syndrome presenting with ovarian dysgerminoma, which implicates PTEN in the molecular pathogenesis of dysgerminoma and adds it to the phenotypic manifestations of Cowden syndrome. 18594467

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0019080
Disease: Hemorrhage
Hemorrhage 		0.010 AlteredExpression LHGDN Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis. 18620995

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0206651
Disease: Clear Cell Sarcoma of Soft Tissue
Clear Cell Sarcoma of Soft Tissue 		0.010 GeneticVariation LHGDN Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. 17646270

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0021368
Disease: Inflammation
Inflammation 		0.010 Biomarker LHGDN Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation. 16325763

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.010 AlteredExpression LHGDN PTEN and p27 expression in mature T-cell and NK-cell neoplasms. 16194892

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0039101
Disease: synovial sarcoma
synovial sarcoma 		0.010 GeneticVariation LHGDN Forty-nine cases of SS were examined for the presence of PTEN gene mutation by polymerase chain reaction - single-strand conformation polymorphism followed by DNA direct sequencing. 15069540

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases 		0.010 Biomarker LHGDN The role of PTEN in the progression and survival of prostate cancer. 12717346

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0085167
Disease: Granular cell tumor
Granular cell tumor 		0.010 GeneticVariation LHGDN Granular cell tumor in a PHTS patient with a novel germline PTEN mutation. 12833416

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell 		0.020 Biomarker LHGDN Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. 16951148

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.020 AlteredExpression LHGDN Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10). 16179636

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0206681
Disease: Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell 		0.030 AlteredExpression LHGDN PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas. 19007975

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.030 AlteredExpression LHGDN PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. 18830414

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023267
Disease: Fibroid Tumor
Fibroid Tumor 		0.030 AlteredExpression LHGDN Our results suggest that the altered phosphorylation of PTEN protein and the consequent activation of survival signals may contribute to the pathomechanism of leiomyoma. 17097286

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.030 GeneticVariation LHGDN Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. 17873882

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.030 GeneticVariation LHGDN PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. 17062663

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.030 AlteredExpression LHGDN The purpose of this study was to determine the effects of adenovirus-mediated overexpression of PTEN on neointimal hyperplasia in vivo in the rat carotid injury model. 15569824

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.030 GeneticVariation LHGDN Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias. 11849740

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma 		0.040 GeneticVariation LHGDN These findings indicate that analysis of PTEN gene mutations may be useful for characterization of the molecular event in hepatic angiosarcoma and cancer predisposition. 17954274

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1961102
Disease: Precursor Cell Lymphoblastic Leukemia Lymphoma
Precursor Cell Lymphoblastic Leukemia Lymphoma 		0.050 AlteredExpression LHGDN Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells. 18599181

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0026948
Disease: Mycosis Fungoides
Mycosis Fungoides 		0.050 GeneticVariation LHGDN Loss of heterozygosity analysis identifies genetic abnormalities in mycosis fungoides and specific loci associated with disease progression. 17895757

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0028945
Disease: oligodendroglioma
oligodendroglioma 		0.070 AlteredExpression LHGDN Herein, we report on comparative genomic hybridization (CGH) and immunohistochemical (IHC) assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas (10 WHO grade II, 3 WHO grade III), one oligoastrocytoma (WHO grade III) and 23 high-grade astrocytomas (3 WHO grade III, 20 glioblastoma multiforme). 17390041

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.070 Biomarker LHGDN Taken together, these findings demonstrate that PTEN potently modulate HBx-mediated signaling and is a viable target in therapeutic approaches to inhibit the formation of HCC caused by HBV infections. 16872708

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.070 AlteredExpression LHGDN Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. 12839924

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.090 GeneticVariation LHGDN PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer. 18609703

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.090 AlteredExpression LHGDN Homeoprotein Cdx2 and nuclear PTEN expression profiles are related to gastric cancer prognosis. 18184409

2007