Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0085167
Disease: Granular cell tumor
Granular cell tumor 		0.010 GeneticVariation LHGDN Granular cell tumor in a PHTS patient with a novel germline PTEN mutation. 12833416

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.070 AlteredExpression LHGDN Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. 12839924

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0085261
Disease: Proteus Syndrome
Proteus Syndrome 		0.700 GeneticVariation LHGDN PTEN mutations are uncommon in Proteus syndrome. 11476065

2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN PTEN gene expression was suppressed in the glioma, which is related to the clinical-pathological results. 17000554

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 Biomarker LHGDN PTEN down-regulation or p53 (+) correlated with increased HCC dedifferentiation, advanced pathologic stages and high PCNA labeling index (LI) of tumors (P<0.05). 17982625

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN PTEN expression and methylation status in oral squamous cell carcinoma. 18497947

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.030 AlteredExpression LHGDN PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. 18830414

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0206681
Disease: Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell 		0.030 AlteredExpression LHGDN PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas. 19007975

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 Biomarker LHGDN A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. 17936563

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 AlteredExpression LHGDN Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion. 17681183

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.440 AlteredExpression LHGDN Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. 12535639

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 Biomarker LHGDN Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. 17911267

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.090 AlteredExpression LHGDN Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. 15900596

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.090 AlteredExpression LHGDN As the activation of PI3K/AKT signaling may be associated with alterations of the PTEN gene located at 10q23.3, a chromosomal region subject to frequent allelic losses in medulloblastoma, we screened PTEN for mutations and mRNA expression. 16707597

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.030 GeneticVariation LHGDN Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias. 11849740

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 GeneticVariation LHGDN Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias. 11849740

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.200 Biomarker LHGDN ATP modulates PTEN subcellular localization in multiple cancer cell lines. 18579579

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 AlteredExpression LHGDN Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate. 18383208

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.500 Biomarker LHGDN Combining PTEN restoration to PTEN-null glioblastoma cells with c-Met and HGF inhibition additively inhibited tumor cell proliferation and cell cycle progression. 19190120

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. 17924977

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN Correlation between NDRG1 and PTEN expression in endometrial carcinoma. 18377423

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 PosttranslationalModification LHGDN Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. 17606718

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 AlteredExpression LHGDN Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer. 16436456

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023418
Disease: leukemia
leukemia 		0.400 AlteredExpression LHGDN Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells. 15725474

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 GeneticVariation LHGDN Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors. 11854177

2002