Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Inhibition of endoplasm reticulum stress by ghrelin protects against ischemiareperfusion injury in rat heart. 19406177

2009

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. 20851484

2011

Entrez Id: 5350
Gene Symbol: PLN
PLN
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. 21934351

2011

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation. 19727523

2009

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Preconditioning with high mobility group box 1 protein protects against myocardial ischemia-reperfusion injury. 19540007

2010

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. 18586023

2008

Entrez Id: 6403
Gene Symbol: SELP
SELP
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model. 21146547

2011

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. 29538428

2018

Entrez Id: 840
Gene Symbol: CASP7
CASP7
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. 29538428

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors. 29299201

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1. 12189448

2002

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. 29538428

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury. 29274587

2018

Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD [Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats]. 25547710

2014

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic/reperfused heart of rat. 18470603

2008

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Diastolic Ca2+ overload caused by Na+/Ca2+ exchanger during the first minutes of reperfusion results in continued myocardial stunning. 17822695

2007

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Roles and relationship of macrophages and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart. 10908159

2000

Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats. 28637456

2017

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. 11934844

2002

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD [Effects of BNP preconditioning on myocardial cell apoptosis and expressions of bcl-2 and Bax during myocardial ischemia-reperfusion injury in rats]. 21223820

2010

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Hyperbaric oxygenation pretreatment induces catalase and reduces infarct size in ischemic rat myocardium. 11510883

2001

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion. 17267548

2007

Entrez Id: 6652
Gene Symbol: SORD
SORD
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. 14525943

2003

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia. 20828747

2010

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. 11934844

2002